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 Delta Plus variant

On Wednesday, India said that it found approximately 40 Delta variant cases that appear to be transmitted by a mutation, and recommended that countries raise their tests.

Below is what the variant we know.

What is the Delta Plus variant of Covid - 19 ?

In the Indian public health newsletter on 11 June, the variant known as "Delta plus" originated in Great Britain.

The subset of the Delta variant, originally detected in India, has the spike protein mutation K417N, found in the first South African Beta variant.

Following reports of several newly detected cases in different parts of the Maharashtra and a number of other states, Delta Plus, the new variant of coronavirus has come to focus.

In Maharashtra, PTI reported quoting State Health Minister Rajesh Tope over 20 cases of Delta Plus infections

The state health authorities said last week that Covid could possibly cause a third wave to the newly identified variant.

As regards the widespread Delta plus, sufficient genome-sequenced samples have not been available. Only approximately 200 sequences have been detected worldwide and in India only about 30.

Where was first detected Delta Plus variant ?

In March of this year, the variant was first seen in Europe. But it was only on 13 June that it became a public domain.

The Delta variant (B.1.617.2) has further mutated, according to researchers, into the Delta Plus variant (AY.1).

virologist seek to know if this new variant is more likely than either Delta or Beta to evade pre-existing immunity.

So far, what are we aware of?

Delta Plus is regarded as highly infectious based on what is known so far. Expert warns that Delta Plus may have shown resistance to monoclonal cocktail antibodies such as Roche and Cipla cocktail treatments in India at high prices are waiving in some quarters (almost Rs. 60,000 per dose).

The new variant could be able to bypass immunity from vaccine as well as early infection, a potential risk of discomfort in the medical community.

However, there is no evidence at the moment that this variant can be more transmissible than other variants, said Professor Shahid Jameel, a former member of INSACOG and one of the leading viral scientists in the country

It is a cause for concern but not for panic. It remains to be seen whether Delta Plus can better overcome previous variants of existing immunity.

Is it more transmissible for Delta Plus variant ?

The mutation K417N — found first in beta is the mutation Delta Plus (South Africa). In conjunction with its ability to have all other features of its predecessor Delta, some scientists think this could make the latest variant more transmissible.

Prof. Jameel stated that the K417N mutation is within the spike protein receptor-binding domain and that change is noteworthy as it is also found in the B.1.35 or Beta variant concern.

Professor Jameel told the news agency ANI that the combination of features from other previous variants could make Delta Plus more suitable for pulling out an immune escape.

Where is the position of India?

Data show that India still has a low prevalence of this new variant. In the country from now on, Delta remains the dominant variant.

In addition to Maharashtra, Tamil Nadu, Kerala, Punjab and Madhya Pradesh have been reported to have seen other states with Delta Plus.

Delta Plus has not yet been categorized as a concern (VOC). It is a variety of interest from now on (VoI).

The potential transmissibility/gravity of the new variant is currently being studied at INSACOG. Studies also investigate whether that variant occurred around the peak of the second wave in India during March-April. A detailed report is expected in the near future.

Is the Delta variant more dangerous?  or   What are Delta Plus chances to spark a Wave 3?

The existing low number does not indicate a trend, and there is no certainty. Even B.1.617 was found in very low numbers before an epic transmissibility level had been reached in the next two and a half months at the center of India's devastating second wave.

How can Delta Plus vaccines be treated? There's no story. Both Indian vaccines showed 3 to 8 times less Delta and Beta efficacy, according to reports. Now it remains to be seen whether it would be neutral, additive or more for this combination of key mutations than the sum of both," said Professor Jameel.

Although Maharashtra claimed that the new variants could trigger a third wave of the state pandemic, other experts have not yet confirmed it. According to NITI Aayog, member of Health, VK Paul, its potential presence in the country is to be watched and an adequate response to public health.

Symptoms of Delta plus variant corona virus.

According to the Union Health Ministry, Delta Plus is highly contagious and is able to bind firmly to the receptor of lung cells. Because of this, there is a possibility of early damage to the lungs.

It is also capable of defeating monoclonal antibody cocktails. The lead researcher who studied the symptoms of Covid, According to Tim Spector, people who have been affected by the delta variant are experiencing severe cough and a different kind of feeling like funny of feeling. 

His cold symptoms are found to be quite different from the previous virus. According to the study, headache, sore throat and runny nose are the most common symptoms associated with the delta variant.

 

 

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